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KMID : 1123920100240030470
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 3 p.470 ~ p.475
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Relation of Paeonia lactiflora Pallas to Nifedipine-induced Gingival Hyperplasia and Impaired Submandibular Glands Function in Rats
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Kim Sung-Hoon
Choi Jong-Won
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Abstract
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Calcium-channel blockers such as nifedipine could be associated with gingival overgrowth. The aim of this study was to examine the role of Paeonia lactiflora Pallas(PLP) on nifedipine-induced gingival hyperplasia along with submandibular secretory function in rats. Animals in divided groups received nifedipine (250 mg/kg) alone and in PLP(100, 200 mg/kg) in orally administration for 3 weeks. Pure submandibular saliva was collected intraorally by micropolyethylene cannula and the mandibular gingiva was examined by means of dissecting microscope for signs of redness, tickness, inflammation and exuda. Twenty-one days nifedipine treatment induced gingival hyperplasia accompanied with reduced salivary flow rate and concentrations total protein, epidermal growth factor(EGF) and calcium in comparison with normals. Co-treatment of animals with nifedifine and PLP protected from gingival hyperplasia and retained flow rate, and concentrations of total protein, EGF and calcium in normal levels.
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KEYWORD
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paeonia lactiflora pallas, nifedipine, gingival hyperplasia, epidermal growth factor
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